Potential Targets and Mechanisms of Phellodendrine in the Treatment of Diabetes Mellitus Based on Network Pharmacology and Molecular Docking

Phellodendrine is a Phellodendri Cortex-derived isoquinoline alkaloids, has been shown to have various activities, especially hypoglycemic effect in mice, predicting its medicinal value on diabetes mellitus. To further understand the pharmacological of phellodendrine mellitus, network techniques used elaborate involved mechanisms. 84 common target molecules were screened, based chemical structure molecule and disease database. These proteins enriched insulin resistance, secretion inflammatory response, mainly focus phosphatidylinositol 3-kinase/protein kinase B signaling pathway, mitogen-activated protein pathway interleukin-17 pathway. Moreover, enrichment analysis suggested that targets such as phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha kinases 8 associated with coronavirus 2019. verify results, molecular docking technique was evaluate interaction between key The calculated binding energy indicates can form stable complex receptor, 8, glycogen synthase 3 beta. data suggest should be beneficial for treatment